Corrigendum: Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals.

نویسندگان

  • Junji Furukawa
  • Katsuhisa Inoue
  • Junya Maeda
  • Tomoya Yasujima
  • Kinya Ohta
  • Yoshikatsu Kanai
  • Tappei Takada
  • Hirotaka Matsuo
  • Hiroaki Yuasa
چکیده

In this Article, we failed to indicate that the term ENBT1 was previously used as the name of a putative transporter involved in the dipyridamole-insensitive, purine-selective nucleobase transport system in primary human cardiac microvascular endothelial cells (ref. 11). More recently, the term has also been used to indicate the cellular function of a dipyridamole-insensitive, sodium-independent equilibrative nucleobase transport mechanism for hypoxanthine in particular cells (Bone DB et al. Am J Physiol Heart Circ Physiol. 299, H847-856, 2010).

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منابع مشابه

Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals

The purine salvage pathway plays a major role in the nucleotide production, relying on the supply of nucleobases and nucleosides from extracellular sources. Although specific transporters have been suggested to be involved in facilitating their transport across the plasma membrane in mammals, those which are specifically responsible for utilization of extracellular nucleobases remain unknown. H...

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Nucleoside and nucleobase transporters are important for salvage of purines and pyrimidines and for transport of their analog drugs into cells. However, the pathways for nucleobase translocation in mammalian cells are not well characterized. We identified an Na-independent purine-selective nucleobase/nucleoside transport system in the nucleoside transporter-deficient PK15NTD cells. This transpo...

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Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity.

Malaria, caused by Plasmodia parasites, affects hundreds of millions of people. As purine auxotrophs, Plasmodia use transporters to import host purines for subsequent metabolism by the purine salvage pathway. Thus purine transporters are attractive drug targets. All sequenced Plasmodia genomes encode four ENTs (equilibrative nucleoside transporters). During the pathogenic intraerythrocytic stag...

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Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy.

Plasmodium, the aetiologic agent of malaria, cannot synthesize purines de novo, and hence depends upon salvage from the host. Here we describe the molecular cloning and functional expression in Xenopus oocytes of the first purine transporter to be identified in this parasite. This 422-residue protein, which we designate PfENT1, is predicted to contain 11 membrane-spanning segments and is a dist...

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Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).

The human equilibrative nucleoside transporters hENT1 and hENT2 (each with 456 residues) are 40% identical in amino acid sequence and contain 11 putative transmembrane helices. Both transport purine and pyrimidine nucleosides and are distinguished functionally by a difference in sensitivity to inhibition by nanomolar concentrations of nitrobenzylmercaptopurine ribonucleoside (NBMPR), hENT1 bein...

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عنوان ژورنال:
  • Scientific reports

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2016